DopaPlus 180 caps

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DopaPlus was developed by Pure Encapsulations in conjunction with Dr. James Greenblatt as part of The Integrative Mental Health Series, a line of products based on scientific findings as well as decades of clinical experience. DopaPlus provides neurotransmitter precursors to help balance dopamine function in the brain for emotional wellness and to enhance daily mental function and sharpness. Also critical to each formulation in this series is the inclusion of a vitamin B6, zinc and Metafolin® L-5-MTHF cofactor complex. These nutrients are often depleted in individuals due to medications, inadequate diets, and toxic environmental exposures, compromising the ability to properly synthesize neurotransmitters. When replete, these cofactors enhance neurotransmitter function and play a complementary role in supporting emotional wellness

DopaPlus Functions: Promotes the production of dopamine to support daily cognitive function and mental tasks*• Provides the dopamine precursors L-tyrosine and L-DOPA from Mucuna pruriens*- In a randomised, controlled, double blind crossover trial, Mucuna pruriens supplementation promoted peak L-DOPA plasma concentrations*• Includes the synergistic cofactors vitamin B6, Metafolin® L-5MTHF, and zinc to support dopamine production; L-5MTHF is the form of folate that easily crosses the blood brain barrier*• Enhances the stability of dopamine and supports healthy reuptake with rhodiola and green tea polyphenols*• Encourages cognitive function and mental sharpness by supporting healthy theta wave activity in the brain with grape seed proanthocyanidins*• Protects neuronal health and function with green tea and grapeseed polyphenols*• Supports optimal serum levels of zinc and folate to promote positive mood*- In a double-blind, randomized and placebo-controlled trial involving young women, zinc supplementation offered statistically significant support for positive mood.

Dopamine neurotransmission: L-tyrosine is converted to L-DOPA by tyrosine hydroxylase (TH), which requires active folate (5-MTHF). Conversion of L-DOPA to dopamine is mediated by aromatic amino acid decarboxylase (AADC), which requires active vitamin B6 (pyridoxal 5’ phosphate). In the communication between neurons, dopamine is released into the synapse, or the space between the two neurons, and subsequently binds to dopamine receptors on the receiving (postsynaptic) neuron. Dopamine receptors translate the message to support cognitive function, mental sharpness and alertness. Dopamine remaining in the synapse is susceptible to reuptake or degradation by two enzymes, monoamine oxidase (MAO) and catechol O-methyltransferase (COMT).

What Is The Source? Pyridoxal 5’ phosphate and folate (Metafolin®, L-5-MTHF) are synthetic. Magnesium and zinc are derived from the lime of rock. L-tyrosine is extracted from protein and extensively processed and purified in a semi-synthetic process. L-DOPA is derived from Mucuna pruriens seeds, the extract is standardized to contain 15% L-DOPA. Rhodiola extract is derived from Rhodiola rosea root and standardized to contain 3% total rosavins and min. 1% salidrosides. Grape seed extract is derived from Vitis vinifera and standardized to contain 92% polyphenols. Green tea extract is derived from Camellia sinensis leaf and standardized to contain 90% total tea catechins and 70% EGCG

.Recommendations: Pure Encapsulations recommends 3-6 capsules daily, in divided doses, between meals

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